In a street somewhere in Hong Kong, there is a detective office called The Three Sisters Detective Agency. Recently they have been hired to escort and protect an author called Sumiregawa Nenene suffering from writer's block and who is looking for Yomiko Readman (aka The Paper). A short time after the I-Jin threat was dealt with, Yomiko and Nancy vanished. Michelle, Maggie, and Anita all possess the power to manipulate and use paper in various ways. Michelle can make weapons, Maggie can create Golems, and Anita is skilled in close-quarter combat, though she hates books. And so the three sisters and an author try to locate "the Paper" and learn the truth about what happened to her.